Seminars in Arthritis and Rheumatism
Volume 40, Issue 1 , Pages 89-94 , August 2010

Is Remitting Seronegative Symmetrical Synovitis with Pitting Edema (RS3PE) a Subset of Rheumatoid Arthritis?

  • Qingping Yao, MD

      Affiliations

    • Rheumatology Fellow, Division of Rheumatology and Immunology, Department of Medicine, David Geffen Medical School at UCLA, Los Angeles, CA
  • ,
  • Xiangqian Su, MD

      Affiliations

    • Visiting Scholar, Molecular and Medical Pharmacology, Jonsson Comprehensive Cancer Center, David Geffen Medical School at UCLA, Los Angeles, CA
  • ,
  • Roy D. Altman, MD

      Affiliations

    • Professor of Medicine, Division of Rheumatology and Immunology, Department of Medicine, David Geffen Medical School at UCLA, Los Angeles, CA
    • Corresponding Author InformationAddress reprint requests to Roy D. Altman, MD, Division of Rheumatology, UCLA, 1000 Veterans Ave., Rehab 39-52, Los Angeles, CA 90095

References 

  1. McCarty DJ, O'Duffy JD, Pearson L, Hunter JB. Remitting seronegative symmetrical synovitis with pitting edema RS3PE syndrome. JAMA. 1985;254(19):2763–2767
  2. Bhakta BB, Pease CT. Late-onset rheumatoid arthritis: is pitting oedema of the hands at onset a good prognostic indicator?. Br J Rheumatol. 1997;36(2):214–219
  3. Kerr LD. Inflammatory arthropathy: a review of rheumatoid arthritis in older patients. Geriatrics. 2004;59(10):32–35
  4. Oide T, Ohara S, Oguchi K, Maruyama M, Yazawa M, Inoue K, et al. Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome in Nagano, Japan: clinical, radiological, and cytokine studies of 13 patients. Clin Exp Rheumatol. 2004;22(1):91–98
  5. Schaeverbeke T, Fatout E, Marcé S, Vernhes JP, Hallé O, Antoine JF, et al. Remitting seronegative symmetrical synovitis with pitting oedema: disease or syndrome?. Ann Rheum Dis. 1995;54(8):681–684
  6. Olivé A, del Blanco J, Pons M, Vaquero M, Tena X. The clinical spectrum of remitting seronegative symmetrical synovitis with pitting edema (The Catalán Group for the Study of RS3PE). J Rheumatol. 1997;24(2):333–336
  7. Toussirot E, Berthier S, Wendling D, Tiberghien P. Lack of association between HLA DRB1* alleles and RS3PE syndrome. Ann Rheum Dis 442;57(7):442.
  8. Klauser A, Frauscher F, Halpern EJ, Mur E, Springer P, Judmaier W, et al. Remitting seronegative symmetrical synovitis with pitting edema of the hands: ultrasound, color Doppler ultrasound, and magnetic resonance imaging findings. Arthritis Rheum. 2005;53(2):226–233
  9. Buchta R. Reflex sympathetic dystrophy in a 14-year-old female. J Adolesc Health Care. 1983;4(2):121–122
  10. van Schaardenburg D, Breedveld FC. Elderly-onset rheumatoid arthritis. Semin Arthritis Rheum. 1994;23(6):367–378
  11. Paira S, Graf C, Roverano S, Rossini J. Remitting seronegative symmetrical synovitis with pitting oedema: a study of 12 cases. Clin Rheumatol. 2002;21(2):146–149
  12. Finnell JA, Cuesta IA. Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome: a review of the literature and a report of three cases. J Foot Ankle Surg. 2000;39(3):189–193
  13. Bucaloiu ID, Olenginski TP, Harrington TM. Remitting seronegative symmetrical synovitis with pitting edema syndrome in a rural tertiary care practice: a retrospective analysis. Mayo Clin Proc. 2007;82(12):1510–1515
  14. Queiro R. RS3PE syndrome: a clinical and immunogenetical study. Rheumatol Int. 2004;24(2):103–105
  15. Gumá M, Casado E, Tena X, Olivé A. RS3PE: six years later. Ann Rheum Dis. 1999;58(11):722–723
  16. Mavragani CP, Moutsopoulos HM. Rheumatoid arthritis in the elderly. Exp Gerontol. 1999;34(3):463–471
  17. Turkcapar N, Demir O, Atli T, Kopuk M, Turgay M, Kinikli G, et al. Late onset rheumatoid arthritis: clinical and laboratory comparisons with younger onset patients. Arch Gerontol Geriatr. 2006;42(2):225–231
  18. Hellier JP, Eliaou JF, Daurès JP, Sany J, Combe B. HLA-DRB1 genes and patients with late onset rheumatoid arthritis. Ann Rheum Dis. 2001;60(5):531–533
  19. Russell EB. Remitting seronegative symmetrical synovitis with pitting edema syndrome: followup for neoplasia. J Rheumatol. 2005;32(9):1760–1761
  20. Gisserot O, Crémades S, Landais C, Leyral G, Bernard P, de Jauréguiberry JP. RS3PE revealing recurrent non-Hodgkin's lymphoma. Joint Bone Spine. 2004;71(5):424–426
  21. Tunc SE, Arslan C, Ayvacioglu NB, Sahin M, Akkus S, Yorgancigil H. Paraneoplastic remitting seronegative symmetrical synovitis with pitting edema (RS3PE syndrome): a report of two cases and review of the literature. Rheumatol Int. 2004;24(4):234–237
  22. Vinci M, Malaguarnera L, Pistone G. RS3PE and ovarian cancer. Ann Rheum Dis. 2001;60(4):429–431
  23. Cantini F, Salvarani C, Olivieri I. Paraneoplastic remitting seronegative symmetrical synovitis with pitting edema. Clin Exp Rheumatol. 1999;17(6):741–744
  24. Sibilia J, Friess S, Schaeverbeke T, Maloisel F, Bertin P, Goichot B, et al. Remitting seronegative symmetrical synovitis with pitting edema (RS3PE): a form of paraneoplastic polyarthritis?. J Rheumatol. 1999;26(1):115–120
  25. Ethiopia A, Bell D. Gastric carcinoma in association with remitting seronegative symmetrical synovitis with pitting edema. J Rheumatol. 1999;26(5):1203–1204
  26. Tada Y, Sato H, Yoshizawa S, Kimura H, Kitamura M, Kusaba T, et al. Remitting seronegative symmetrical synovitis with pitting edema associated with gastric carcinoma. J Rheumatol. 1997;24(5):974–975
  27. Mattace-Raso FU, van der Cammen TJ. Remitting seronegative symmetrical synovitis with pitting oedema associated with lung malignancy. Age Ageing. 2007;36(4):470–471
  28. Olivo D, Mattace R. Concurrence of benign edematous polysynovitis in the elderly (RS3PE syndrome) and endometrial adenocarcinoma. Scand J Rheumatol. 1997;26(1):67–68
  29. Nakashima H, Tanaka Y, Shigematsu H, Kanaya S, Otsuka T, Hayashida K, et al. Remitting seronegative symmetrical synovitis with pitting edema syndrome associated with cryptogenic hepatocellular carcinoma. Clin Exp Rheumatol. 1999;17(3):390–391
  30. Goldenberg K, Rozenbaum M, Rosner I, Naschitz J, Kotler C. Remitting symmetric seronegative synovitis with pitting edema (RS3PE) secondary to non-Hodgkin's lymphoma. Clin Exp Rheumatol. 1998;16(6):767–768
  31. Cobeta-Garcia JC, Domingo-Morera JA, Martínez-Burgui J. RS3PE syndrome and chronic lymphoid leukaemia. Clin Exp Rheumatol. 1999;17(2):266–267
  32. Chiappetta N, Gruber B. Remitting seronegative symmetrical synovitis with pitting edema associated with acute myeloid leukemia. J Rheumatol. 2005;32(8):1613–1614
  33. Ekenel M, Yavuz S, Karti S, Direskeneli H, Akoşlu T. Remitting seronegative symmetrical synovitis with pitting oedema associated with chronic lymphocytic leukaemia. Clin Rheumatol. 2000;19(3):247–248
  34. Manganelli P, Delsante G, Bianchi G, Fietta P, Quaini F. Remitting seronegative symmetrical synovitis with pitting oedema in a patient with myelodysplastic syndrome and relapsing polychondritis. Clin Rheumatol. 2001;20(2):132–135
  35. Hansen J. Common cancers in the elderly. Drugs Aging. 1998;13(6):467–478
  36. Smitten AL, Simon TA, Hochberg MC, Suissa S. A meta-analysis of the incidence of malignancy in adult patients with rheumatoid arthritis. Arthritis Res Ther. 2008;10(2):R45
  37. Fietta P, Manganelli P. Sjögren's syndrome presenting as remitting seronegative symmetric synovitis with pitting edema (RS3PE): comment of the article by Choi et al. J Korean Med Sci. 2003;18(6):921
  38. Billey T, Navaux F, Lassoued S. Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) as the first manifestation of periarteritis nodosa (Report of a case). Rev Rhum Engl Ed. 1995;62(1):53–54
  39. Koeger AC, Karmochkine M, Chaïbi P. RS3PE syndrome associated with advanced ankylosing spondylitis. J Rheumatol. 1995;22(2):375–376
  40. Matsuda M, Sakurai K, Fushimi T, Yamamoto K, Rokuhara S, Hosaka N, et al. Sarcoidosis with high serum levels of vascular endothelial growth factor (VEGF), showing RS3PE-like symptoms in extremities. Clin Rheumatol. 2004;23(3):246–248
  41. Magy N, Michel F, Auge B, Toussirot E, Wendling D. Amyloid arthropathy revealed by RS3PE syndrome. Joint Bone Spine. 2000;67(5):475–477
  42. Kato T, Ubara Y, Sawa N, Tagami T, Katori H, Takemoto F, et al. An abrupt onset of seropositive polyarthritis with prominent distal tenosynovitis concomitant with bronochiolitis obliterans organizing pneumonia (BOOP): consideration of the relationship with RS3PE syndrome. Intern Med. 2004;43(2):143–147
  43. Arima K, Origuchi T, Tamai M, Iwanaga N, Izumi Y, Huang M, et al. RS3PE syndrome presenting as vascular endothelial growth factor associated disorder. Ann Rheum Dis. 2005;64(11):1653–1655
  44. Ito EOH, Mochizuki A, Ohara K, Kato M, Terashima Y, Tanaka E, et al. Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome accompanied by Parkinson's disease. Intern Med. 2007;46(14):1139–1142
  45. Baumgartner I, Rauh G, Pieczek A, Wuensch D, Magner M, Kearney M, et al. Lower-extremity edema associated with gene transfer of naked DNA encoding vascular endothelial growth factor. Ann Intern Med. 2000;132(11):880–884
  46. El Mahou S, Popa L, Constantin A, Cantagrel A, Aberrane A, Jamard B, et al. Remitting seronegative symmetrical synovitis pitting oedema after BCG instillation. Clin Rheumatol. 2006;25(4):566–567
  47. Mouly S, Berenbaum F, Kaplan G. Remitting seronegative symmetrical synovitis with pitting edema following intravesical bacillus Calmette-Guérin instillation. J Rheumatol. 2001;28(7):1699–1701
  48. Perandones CE Colmegna I, Arana RM. Parvovirus B19: another agent associated with remitting seronegative symmetrical synovitis with pitting edema. J Rheumatol. 2005;32(2):389–390
  49. Torres A, Cuende E, De Pablos M, Lezaun MJ, Michaus L, Vesga JC. Remitting seronegative symmetrical synovitis with pitting edema associated with subcutaneous Streptobacillus moniliformis abscess. J Rheumatol. 2001;28(7):1696–1698
  50. Russell EB, McCarty DJ, Schwab J, Hanel D, Komorowski R, Stransky G, et al. RS3PE syndrome: no evidence for retroviruses. J Rheumatol. 1994;21(6):1105–1106
  51. Schaeverbeke T, Vernhes JP, Bannwarth B, Dehais J. Is remitting seronegative symmetrical synovitis with pitting oedema (RS3PE syndrome) associated with HLA-A2?. Br J Rheumatol. 1995;34(9):889–890
  52. Bowes J, Barton A. Recent advances in the genetics of RA susceptibility. Rheumatology (Oxford). 2008;47(4):399–402

 The authors have no conflicts of interest to disclose.

PII: S0049-0172(08)00214-X

doi: 10.1016/j.semarthrit.2008.11.006

Seminars in Arthritis and Rheumatism
Volume 40, Issue 1 , Pages 89-94 , August 2010