Seminars in Arthritis and Rheumatism
Volume 39, Issue 6 , Pages 442-447 , June 2010

The Effect of Infliximab and Timing of Vaccination on the Humoral Response to Influenza Vaccination in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis

  • Ori Elkayam, MD

      Affiliations

    • Department of Rheumatology, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel
    • Department of Internal Medicine “F”, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel
    • Corresponding Author InformationAddress reprint requests to Ori Elkayam, MD, Department of Rheumatology, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv 64239, Israel
  • ,
  • Amir Bashkin, MD

      Affiliations

    • Department of Rheumatology, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel
  • ,
  • Michal Mandelboim, PhD

      Affiliations

    • Central Virology Laboratory, Ministry of Health, Chaim Sheba Medical Center, Tel Hashomer, Israel Tel Aviv Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel
  • ,
  • Irena Litinsky, MD

      Affiliations

    • Department of Rheumatology, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel
  • ,
  • Doron Comaheshter

      Affiliations

    • Statistic Unit, Tel Aviv Sourasky Medical Center, Tel-Aviv, Israel
  • ,
  • David Levartovsky, MD

      Affiliations

    • Department of Rheumatology, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel
  • ,
  • Ella Mendelson, PhD

      Affiliations

    • Central Virology Laboratory, Ministry of Health, Chaim Sheba Medical Center, Tel Hashomer, Israel Tel Aviv Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel
  • ,
  • Irena Wigler, MD

      Affiliations

    • Department of Rheumatology, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel
  • ,
  • Dan Caspi, MD

      Affiliations

    • Department of Rheumatology, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel
  • ,
  • Daphna Paran, MD

      Affiliations

    • Department of Rheumatology, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel

References 

  1. Gabriel SE, Crowson CS, Kremers NM, Doran MF, Turesson C, O'Fallozn WM, et al. Mortality in rheumatoid arthritis: have we made impacts in 4 decades?. Arthritis Rheum. 2003;48:54–58
  2. Symmons DP, Jones MA, Scott DL. Long-term mortality outcome in patients with rheumatoid arthritis: early presenters continue to do well. J Rheumatol. 1998;25:1072–1077
  3. Doran MF, Crowson CS, Pond GR, O'Fallon WM, Gabriel SE. Frequency of infection in patients with rheumatoid arthritis compared with controls. Arthritis Rheum. 2002;46:2287–2293
  4. Bongartz T, Sutton AJ, Sweeting MJ, Buchan I, Matteson EL, Montori V. Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: systematic review and meta-analysis of rare harmful effects in randomized controlled trials. JAMA. 2006;295(19):2275–2285
  5. Smith NM, Bresee JS, Shay DK, Uyeki TM, Cox NJ, Strikas RA. Prevention and Control of Influenza: Recommendation of the Advisory Committee on Immunization Practices (ACIP). National Center for Immunization and Respiratory Diseases (proposed). CDC July 28, 2006/55(RR10):1-42.
  6. Fomin I, Caspi D, Levy V, Varsano N, Shalev Y, Paran D, et al. Vaccination against influenza in rheumatoid arthritis: the effect of disease modifying drugs, including TNF alpha blockers. Ann Rheum Dis. 2006;65:191–194
  7. Chalmers A, Scheifele D, Patterson C, Williams D, Weber J, Shuckett R, et al. Immunization of patients with rheumatoid arthritis against influenza: a study of vaccine safety and immunogenicity. J Rheumatol. 1994;21:1203–1206
  8. Kapetanovic MC, Saxne T, Nilsson JA, Geborek P. Influenza vaccination as model for testing immune modulation induced by anti-TNF and methotrexate therapy in rheumatoid arthritis patients. Rheumatology (Oxford). 2007;46(4):608–611[Epub 2006 Nov 18].
  9. Arnett FC, Edworthy SM, Bloch DA. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 1988;31:315–324
  10. Van der Linden S, Valkenburg HA, Cats A. Evaluation of diagnostic criteria for ankylosing spondylitis: a proposal for modification of the New York criteria. Arthritis Rheum. 1984;27:361–368
  11. Prevoo ML, van't Hof MA, Kuper HH, van Leeuwen MA, van de Putte LB, van Riel PL. Modified disease activity scores that include twenty-eight-joint counts. Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis Rheum. 1995;38:44–48
  12. Garrett S, Jenkinson T, Kennedy LG, Whitelock H, Gaisford P, Calin A. A new approach to defining disease status in ankylosing spondylitis: the Bath Ankylosing Spondylitis Disease Activity Index. J Rheumatol. 1994;21:2286–2291
  13. Committee for Proprietary Medicinal Products (CPMC). Note for guidance on harmonization of requirements for influenza vaccines. CPMB/BWP/214/96, 1996, Circular No. 96-0666:1-22.
  14. Committee for Proprietary Medicinal Products (CPMC). Concept paper on the revision of the CPMP/BWP note for guidance on harmonization of requirements for influenza vaccines, 2001, CPMP/EPW/1045/01.
  15. Palmer DF, Coleman MT, Dowdle DC, Schild DC. Advanced laboratory techniques for influenza diagnosis (Public Health Service. US Department of Health, Education and Welfare). Atlanta (GA): Centers for Disease Control; 1975;
  16. Gelinck LB, van der Bijl AE, Beyer WE, Visser LG, Huizinga TW, van Hogezand RA, et al. The effect of anti-tumor necrosis factor alpha treatment on the antibody response to influenza vaccination. Ann Rheum Dis. 2007 Oct 26;[Epub ahead of print].
  17. Kaine JL, Kivitz AJ, Birbara C, Luo AY. Immune responses following administration of influenza and pneumococcal vaccines to patients with rheumatoid arthritis receiving adalimumab. J Rheumatol. 2007;34(2):272–279
  18. Klotz U, Teml A, Schwab M. Clinical pharmacokinetics and use of infliximab. Clin Pharmacokinet. 2007;46(8):645–660

PII: S0049-0172(08)00216-3

doi: 10.1016/j.semarthrit.2008.12.002

Seminars in Arthritis and Rheumatism
Volume 39, Issue 6 , Pages 442-447 , June 2010