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Seminars in Arthritis and Rheumatism
Volume 40, Issue 2
, Pages 147-163
, October 2010
Tumor Necrosis Factor Inhibitors and Lung Disease: A Paradox of Efficacy and Risk
References
- . Infections associated with tumor necrosis factor-alpha antagonists. Pharmacotherapy. 2005;25(9):1181–1192
- . Problems encountered during anti-tumour necrosis factor therapy. Best Pract Res Clin Rheumatol. 2006;20(4):757–790
- A metalloproteinase disintegrin that releases tumour necrosis factor-alpha from cells. Nature. 1997;385:729–733
- Pulmonary Hypoplasia in mice lacking tumor necrosis factor-alpha converting enzyme indicates an indispensable role for cell surface protein shedding during embryonic lung branching morphogenesis. Dev Biol. 2001;232(1):204–218
- Apoptosis and loss of adhesion of bronchial epithelial cells in asthma. Int Arch Allergy Immunol. 2005;138(2):142–150
- . Effects of TNF-alpha, IFN-gamma and IL-beta on normal human bronchial epithelial cells. Eur Respir J. 1999;14(1):84–91
- . A new class of reverse signaling costimulators belongs to the TNF family. J Immunol. 2007;179(7):4307–4312
- . Tumor necrosis factor: receptor binding and mitogenic action in fibroblasts. J Cell Physiol Suppl. 1987;(Suppl 5):57–61
- . In situ localization of TNF alpha/beta (TACE and TNF receptors TNF-R1 and TNF-R2 in control and LPS-treated lung tissue). Cytokine. 2003;22(3-4):89–100
- . Role of TNF-alpha in lung tight junction alteration in mouse model of acute lung inflammation. Respir Res. 2007;8:75
- . Surfactant-associated protein A inhibits LPS-induced cytokine and nitric oxide production in vivo. Am J Physiol Lung Cell Mol Physiol. 2000;278(4):L840–L847
- . TNF-alpha inhibits SP-A gene expression in lung epithelial cells via p38 MAPK. Am J Physiol Lung Cell Mol Physiol. 2002;283(2):L418–L427
- . Chemical genetic analysis of the time course of signal transduction by JNK. Mol Cell. 2006;21(5):701–710
- . Activation of Rho kinase by TNF-alpha is required for JNK activation in human pulmonary microvascular endothelial cells. J Immunol. 2008;180(1):550–558
- . TNF-alpha induced bronchial vasoconstriction. Am J Physiol Heart Circ Physiol. 2000;279(3):H946–H951
- Tumor necrosis factor-alpha overexpression in lung disease: a single cause behind a complex phenotype. Am J Respir Crit Care Med. 2005;171(12):1363–1370
- . Cytokines in chronic obstructive pulmonary disease. Curr Drug Targets Inflamm Allergy. 2005;4(6):619–625
- . Tumor necrosis factor-alpha-mediated decrease in glutathione increases the sensitivity of pulmonary vascular endothelial cells to H2O2. J Clin Invest. 1992;89(3):794–802
- . Rapid reactive oxygen species production by mitochondria in endothelial cells exposed to tumor necrosis factor-alpha is mediated by ceramide. Am J Respir Cell Mol Biol. 2001;24(6):762–768
- . Targets of anticytokine therapy and the risk of infections in humans and mice. Curr Opin Rheumatol. 2007;19(6):626–635
- Structural deficiencies in granuloma formation in TNF gene-targeted mice underlie the heightened susceptibility to aerosol Mycobacterium tuberculosis infection, which is not compensated for by lymphotoxin. J Immunol. 1999;162(6):3504–3511
- . Restraining mycobacteria: role of granulomas in mycobacterial infections. Immunol Cell Biol. 2000;78(4):334–341
- . Cytokine responses during mycobacterial and schistosomal antigen-induced pulmonary granuloma formation (Production of Th1 and Th2 cytokines and relative contribution of tumor necrosis factor). Am J Pathol. 1994;145(5):1105–1113
- . Immunohistochemical analysis of cytokines and apoptosis in tuberculous lymphadenitis. Immunology. 2006;117(4):454–462
- Distribution of IFN-gamma (IL-4 and TNF-alpha protein and CD8 T cells producing IL-12p40 mRNA in human lung tuberculous granulomas). Immunology. 2002;105(3):325–335
- . In situ production of gamma interferon, interleukin-4, and tumor necrosis factor alpha mRNA in human lung tuberculous granulomas. Infect Immun. 2000;68(5):2827–2836
- . Experimental epithelioid cell granulomas, tubercle formation and immunological competence: an ultrastructural analysis. J Pathol. 1983;141(2):97–112
- . Th1/Th2 cell distribution in pulmonary sarcoidosis. Am J Respir Cell Mol Biol. 1997;16:171–177
- Alveolar macrophages are the main source for tumour necrosis factor-alpha in patients with sarcoidosis. Eur Respir J. 2003;21:421–428
- . Association of TNF polymorphisms with sarcoidosis, its prognosis and tumour necrosis factor (TNF)-alpha levels in Asian Indians. Clin Exp Immunol. 2008;151(2):251–259
- . The role of protected extracellular compartments in interactions between leukocytes, and platelets, and fibrin/fibrinogen matrices. Ann NY Acad Sci. 1992;667:163–172
- . Activity of a macrophage factor in collagen formation by silica. Nature. 1967;214:521–522
- . A macrophage-dependant factor that stimulates the proliferation of fibroblasts in vitro. Am J Pathol. 1976;84:501–513
- . Hydrolytic enzymes of alveolar macrophages. Rev Infect Dis. 1983;5(6):1078–1092
- . Immune mediators increase adherence of T-lymphocytes to human lung fibroblasts. Am J Physiol. 1989;256(2 Pt. 1):C336–C340
- . Requirement of tumour necrosis factor for development of silica-induced pulmonary fibrosis. Nature. 1990;344(6263):245–247
- . Cytokines and pulmonary fibrosis. Thorax. 1993;48(9):931–935
- . Regulation of rat pulmonary artery endothelial cell transforming growth factor-beta production by IL-1 beta and tumor necrosis factor-alpha. J Immunol. 1992;149(1):103–106
- . Fibroblast growth factors in connective tissue disease associated interstitial lung disease. Clin Exp Immunol. 1992;90(3):447–452
- . The controversial role of tumor necrosis factor alpha in fibrotic diseases. Arthritis Rheum. 2008;58(8):2228–2235
- Myocardial extracellular matrix remodeling in transgenic mice overexpressing tumor necrosis factor alpha can be modulated by anti-tumor necrosis factor alpha therapy. Proc Natl Acad Sci USA. 2000;97(23):12746–12751
- . Bidirectional modulation of TNF-alpha production by alveolar macrophages in asbestos-induced pulmonary fibrosis. J Leukoc Biol. 1993;53(3):279–286
- . Tumor necrosis factor-induced expression of platelet-derived growth factor A-chain messenger RNA in fibroblasts. Exp Cell Res. 1989;180:490–496
- . Liver collagenase in murine schistosomiasis. Gastroenterology. 1980;78(6):1425–1431
- . Effect of chemotherapy on hepatic collagen and glycosaminoglycan metabolism in Schistosoma mansoni-infected mice. Trans R Soc Trop Med Hyg. 1988;82(6):868–873
- . Collagen isotypes, and fibronectin in granulomas of the liver and intestines of Schistosoma mansoni-infected mice. Am J Trop Med Hyg. 1987;37(2):335–344
- Increased secretion of tumor necrosis factor alpha and interleukin-6 by alveolar macrophages consecutive to the development of the late asthmatic reaction. J Allergy Clin Immunol. 1991;88(4):561–571
- Human lung mast cells and pulmonary macrophages produce tumor necrosis factor-α in sensitized lung tissue after IgE receptor triggering. Am J Respir Cell Mol Biol. 1992;7:385–392
- . Evaluation of the anti-inflammatory effect of infliximab in a mouse model of acute asthma. Respirology. 2008;13(4):488–497
- . Infliximab therapy for rheumatoid arthritis (RA) induced significant control of asthma in patients with both RA and asthma or asthma/COPD in addition to improving RA status. J. Allergy Clin Immunol. 2002;109(Suppl 1):s243
- Evidence of a role of tumor necrosis factor alpha in refractory asthma. N Engl J Med. 2006;354(7):697–708
- The effects of a monoclonal antibody directed against tumor necrosis factor-alpha in asthma. Am J Respir Crit Care Med. 2006;174(7):753–762
- A randomized, double-blind, placebo-controlled study of tumor necrosis factor-alpha blockade in severe persistent asthma. Am J Respir Crit Care Med. 2009;179(7):549–558
- . Inhibition of tumor necrosis factor alpha for refractory asthma. N Engl J Med. 2006;354(7):754–758
- Inhibition of tumor necrosis factor-alpha reduces alveolar septal cell apoptosis in passive smoking rats. Chin Med J (Engl). 2008;121(7):597–601
- . First study of infliximab treatment in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2005;172(4):465–469
- The safety and efficacy of infliximab in moderate to severe chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2007;175(9):926–934
- . Study of infliximab treatment in smokers with COPD: what next?. Am J Respir Crit Care Med. 2005;172(12):1607–1608
- . Unexpected failure of anti-tumor necrosis factor therapy in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2007;175:866–867
- . Infliximab for refractory sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis. 2001;18(1):70–74
- . Treatment of complicated sarcoidosis with infliximab anti-tumor necrosis factor-alpha therapy. Ann Intern Med. 2001;135(1):27–31
- . Treatment of sarcoidosis with infliximab. Chest. 2005;127(3):1064–1071
- . A systematic review of the off-label use of biological therapies in systemic autoimmune diseases. Medicine (Baltimore). 2008;87(6):345–364
- Infliximab therapy in patients with chronic sarcoidosis and pulmonary involvement. Am J Respir Crit Care Med. 2006;174(7):795–802
- A double-blinded, randomized, placebo-controlled trial of infliximab in subjects with active pulmonary sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis. 2006;23(3):201–208
- . Treatment of therapy-resistant sarcoidosis with adalimumab. Clin Rheumatol. 2006;25(4):596–597
- . Etanercept ameliorates sarcoidosis arthritis and skin disease. J Rheumatol. 2003;30(8):1864–1867
- Etanercept for the treatment of stage II and III progressive pulmonary sarcoidosis. Chest. 2003;124(1):177–185
- . Expression and localization of tumor necrosis factor-alpha and its mRNA in idiopathic pulmonary fibrosis. Am J Pathol. 1993;143(3):651–655
- . Clinical response of rheumatoid arthritis-associated pulmonary fibrosis to tumor necrosis factor-alpha inhibition. Chest. 2002;122(3):1093–1096
- Bargagli E, Galeazzi M, Rottoli P. Infliximab treatment in a patient with rheumatoid arthritis and pulmonary fibrosis. Eur Respir J 708;24(4):708.
- Infliximab therapy in pulmonary fibrosis associated with collagen vascular disease. Clin Exp Rheumatol. 2007;25(1):23–28
- . Anti-tumor necrosis factor therapy: 6 year experience of a single center in northern Israel and possible impact of health policy on results. Isr Med Assoc J. 2008;10(4):277–281
- Treatment of idiopathic pulmonary fibrosis with etanercept: an exploratory, placebo-controlled trial. Am J Respir Crit Care Med. 2008;178(9):948–955
- Autoimmune diseases induced by TNF-targeted therapies: analysis of 233 cases. Medicine (Baltimore). 2007;86(4):242–251
- . Sarcoidosis during anti-TNF-alpha treatment for inflammatory rheumatic diseases: report of two cases. Clin Exp Rheumatol. 2008;26(3):471–475
- . Development of sarcoidosis in etanercept-treated rheumatoid arthritis patients. Clin Rheumatol. 2007;26(11):1969–1971
- . Pulmonary sarcoidosis developing during infliximab therapy. Arthritis Rheum. 2006;55(6):978–981
- Sarcoid-like granulomatous disease following etanercept treatment for RA. J Rheumatol. 2007;34(3):648–649
- . Relapse of sarcoidosis upon treatment with etanercept. Ann Rheum Dis. 2008;67(6):896–898
- Development of sarcoidosis during etanercept therapy. Intern Med. 2008;47(11):1021–1025
- . Development of sarcoidosis during etanercept therapy. Arthritis Rheum. 2006;55(5):817–820
- . Pulmonary sarcoidosis associated with etanercept therapy. Pharmacotherapy. 2007;27(10):1446–1448
- . Granulomatous lung disease occurring during etanercept treatment. Arthritis Rheum. 2005;53(4):618–620
- . Pulmonary sarcoidosis in a patient with ankylosing spondylitis treated with infliximab. Clin Exp Rheumatol. 2007;25(1):99–101
- . Tumor necrosis factor inhibition in the treatment of refractory sarcoidosis: slaying the dragon?. J Rheumatol. 2007;34(11):2129–2131
- Noninfectious lung pathology in patients with Crohn's disease. Am J Surg Pathol. 2003;27(2):213–219
- . Coexistence of rheumatoid arthritis and sarcoidosis: difficulties encountered in the differential diagnosis of common manifestations. J Rheumatol. 1984;11(4):526–529
- Rheumatoid lung nodulosis and osteopathy associated with leflunomide therapy. Clin Rheumatol. 2006;25(3):384–388
- . Effects of tumor necrosis factor-alpha inhibitors on lung lesions with rheumatoid arthritis. Chest. 2003;124(1):413–414
- . Biologic therapy (TNF-alpha antagonists)-induced psoriasis: a cytokine imbalance between TNF-alpha and IFN-alpha?. J Clin Rheumatol. 2008;14(6):353–356
- . Severe interstitial pneumonitis associated with infliximab therapy. Scand J Rheumatol. 2004;33(4):276–277
- Ostor AJ, Crisp AJ, Somerville MF, Scott DG. Fatal exacerbation of rheumatoid arthritis associated fibrosing alveolitis in patients given infliximab. BMJ 1266;329(7477):1266.
- . TNF blockade in rheumatoid arthritis can cause severe fibrosing alveolitis (Six case reports). Lakartidningen. 2005;102(49):3788–37903793
- . Acute progression of interstitial lung disease: a complication of etanercept particularly in the presence of rheumatoid lung and methotrexate treatment. Rheumatology (Oxford). 2006;45(8):1048–1049
- . Exacerbation of interstitial lung disease during etanercept therapy: two cases. Joint Bone Spine. 2008;75(2):215–218
- . Acute exacerbation of preexisting interstitial lung disease after administration of etanercept for rheumatoid arthritis. J Rheumatol. 2007;34(5):1151–1154
- . Adalimumab-associated pulmonary fibrosis. Rheumatology (Oxford). 2006;45(10):1312–1313
- . Pulmonary fibrosis in a patient with rheumatoid arthritis treated with adalimumab. Arthritis Rheum. 2006;55(1):157–159
- . Interstitial pneumonitis associated with infliximab therapy. J Rheumatol. 2006;33(6):1189–1193
- . Development of interstitial pneumonia in a rheumatoid arthritis patient treated with infliximab, an anti-tumor necrosis factor alpha-neutralizing antibody. Mod Rheumatol. 2006;16(4):251–255
- . Interstitial pneumonitis after infliximab therapy for Crohn's disease. Inflamm Bowel Dis. 2006;12(5):427–428
- . Enbrel-induced interstitial lung disease. South Med J. 2006;99(7):783–784
- . Fatal exacerbation of fibrosing alveolitis associated with systemic sclerosis in a patient treated with adalimumab. Ann Rheum Dis. 2006;65(6):834–835
- . Anti-tumour necrosis factor therapy for severe inflammatory arthritis: two years of experience in Northern Ireland. Ulster Med J. 2002;71:101–105
- . Rheumatoid arthritis treatment and the risk of severe interstitial lung disease. Scand J Rheumatol. 2007;36(3):172–178
- http://www.bjdonline.org/default.aspx?contId=944. BSRBR Newsletter August 2004 by BSRBR—published in BSR, 2005-08-31.
- Infliximab (chimeric anti-tumour necrosis factor alpha monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: a randomised phase III trial (ATTRACT Study Group). Lancet. 1999;354(9194):1932–1939
- . Inflammatory Interstitial Lung Disease in rheumatoid arthritis patients treated with biologic treatment (Incidence and mortality rates compared with patients non receiving biologics). Ann Rheum Dis. 2005;64(Suppl III):470
- . Biologic therapy: a countrywide survey of anti-TNF use and associated complications. Ann Rheum Dis. 2006;65(Suppl II):499
- . BSRBR Control Centre Consortium; British Society for Rheumatology Biologics Register (Baseline comorbidity levels in biologic and standard DMARD treated patients with rheumatoid arthritis: results from a national patient register). Ann Rheum Dis. 2006;65(7):895–898
- . Uniform databases in early arthritis: specific measures to complement classification criteria and indices of clinical change. Clin Exp Rheumatol. 2003;21(5 Suppl 31):S79–S88
- . Methotrexate pneumonitis after initiation of infliximab therapy for rheumatoid arthritis. Arthritis Rheum. 2002;47(6):670–671
- . Comment on methotrexate pneumonitis after initiation of infliximab therapy for rheumatoid arthritis. Arthritis Rheum. 2003;49(4):617;author reply, 617-8
- . Leflunomide use and the risk of interstitial lung disease in rheumatoid arthritis. Arthritis Rheum. 2006;54(5):1435–1439
- . The use of biologic agents for severe inflammatory arthritis in Northern Ireland (EULAR). [FRI0017] Abstract Archive http://www.abstracts2view.com/eular/sessionindex.php2004;
- American College of Rheumatology 2008 recommendations for the use of nonbiologic and biologic disease-modifying antirheumatic drugs in rheumatoid arthritis. Arthritis Rheum. 2008;59(6):762–784
- . Update on the British Society for Rheumatology guidelines for prescribing TNF alpha blockers in adults with rheumatoid arthritis (update of previous guidelines of April 2001). Rheumatology (Oxford). 2005;44(2):157–163
- Updated consensus statement on biological agents for the treatment of rheumatic diseases, 2008. Ann Rheum Dis. 2008;67(Suppl III):iii2–iii25
- . Idiopathic pulmonary fibrosis: diagnosis and treatment (International consensus statement. American Thoracic Society (ATS), and the European Respiratory Society (ERS)). Am J Respir Crit Care Med. 2000;161(2 Pt. 1):646–664
- http://www.nice.org.uk/nicemedia/pdf/TA130guidance.pdf.
- http://www.rxabbott.com/pdf/humira.pdf.
- http://www.remicade.com/remicade/assets/HCP_PPI.pdf.
- http://www.enbrel.com/pdf/enbrel_pi.pdf.
- . Incidence and incidence density of death in controlled clinical trials of anti-TNF drugs in rheumatoid arthritis. Ann Rheum Dis. 2005;64(Suppl III):464
- . The safety of anti-tumour necrosis factor therapy in rheumatoid arthritis. Curr Opin Rheumatol. 2008;20(2):138–144
- . Antithrombotic activity of TNF-alpha. J Clin Invest. 2003;112(10):1589–1596
- . Infliximab therapy in rheumatoid arthritis and ankylosing spondylitis-induced specific antinuclear and antiphospholipid autoantibodies without autoimmune clinical manifestations: a two-year prospective study. Arthritis Res Ther. 2004;6(6):R535–R543
- . Diffuse alveolar hemorrhage after infliximab treatment of Crohn's disease. Inflamm Bowel Dis. 2004;10(3):274–277
- . Polymyositis associated with infliximab treatment for rheumatoid arthritis. Rheumatology (Oxford). 2003;42(12):1566–1568
The authors have no conflicts of interest to disclose.
PII: S0049-0172(09)00115-2
doi: 10.1016/j.semarthrit.2009.09.001
© 2010 Elsevier Inc. All rights reserved.
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Seminars in Arthritis and Rheumatism
Volume 40, Issue 2
, Pages 147-163
, October 2010
