« Previous
Next »
Seminars in Arthritis and Rheumatism
Volume 40, Issue 2
, Pages 164-175
, October 2010
The Involvement of Heat-Shock Proteins in the Pathogenesis of Autoimmune Arthritis: A Critical Appraisal
References
- . Rheumatoid arthritis. In: Kasper D, Braunwald E, Fauci A, Hauser S, Longo D, Jameson J editor. Harrison's Principles of Internal Medicine. 16th edition. New York (NY): McGraw-Hill; 2005;p. 1968–1977
- Estimates of the prevalence of arthritis and selected musculoskeletal disorders in the United States. Arthritis Rheum. 1998;41(5):778–799
- . Rheumatoid arthritis (Pathophysiology and implications for therapy). N Engl J Med. 1990;322(18):1277–1289
- . The heat-shock proteins. Annu Rev Genet. 1988;22:631–677
- . Chaperonins Biochem J. 1998;333(Pt. 2):233–242
- . Roles of heat-shock proteins in innate and adaptive immunity. Nat Rev Immunol. 2002;2(3):185–194
- . SnapShot: molecular chaperones. Part I (Cell). 2007;128(1):212
- . Lines of T lymphocytes induce or vaccinate against autoimmune arthritis. Science. 1983;219(4580):56–58
- Cloning of the mycobacterial epitope recognized by T lymphocytes in adjuvant arthritis. Nature. 1988;331(6152):171–173
- . Inhibition of adjuvant arthritis by a DNA vaccine encoding human heat shock protein 60. J Immunol. 2002;169(6):3422–3428
- Diversification of T cell responses to carboxy-terminal determinants within the 65-kD heat-shock protein is involved in regulation of autoimmune arthritis. J Exp Med. 1997;185(7):1307–1316
- Resistance to adjuvant arthritis is due to protective antibodies against heat shock protein surface epitopes and the induction of IL-10 secretion. J Immunol. 2002;168(12):6463–6469
- Modulation of pristane-induced arthritis by mycobacterial antigens. Autoimmunity. 1991;11(1):35–43
- . Protection against streptococcal cell wall-induced arthritis by pretreatment with the 65-kD mycobacterial heat shock protein. J Exp Med. 1989;170(2):449–466
- . Heat shock protein 65-reactive T cells are involved in the pathogenesis of non-antigenic dimethyl dioctadecyl ammonium bromide-induced arthritis. J Immunol. 2005;175(1):219–227
- . The route of administration of an immunodominant peptide derived from heat-shock protein 65 dramatically affects disease outcome in pristane-induced arthritis. Immunology. 2000;99(3):338–344
- Expression of heat shock protein receptors on fibroblast-like synovial cells derived from rheumatoid arthritis-affected joints. Rheumatol Int. 2008;28(9):837–844
- Small molecule inhibitors of Hsp90 potently affect inflammatory disease pathways and exhibit activity in models of rheumatoid arthritis. Arthritis Rheum. 2008;58(12):3765–3775
- . Characteristics of synovial fluid effusion in collagen-induced arthritis (CIA) in the DA rat; a comparison of histology and antibody reactivities in an experimental chronic arthritis model and rheumatoid arthritis (RA). Clin Exp Immunol. 1997;107(3):480–484
- Antibody response to the human stress protein BiP in rheumatoid arthritis. Rheumatology (Oxford). 2004;43(10):1283–1287
- . Frequency of anti-hsp60, -65 and -70 antibodies in sera of patients with juvenile idiopathic arthritis. J Autoimmun. 2006;27(2):81–88
- . Antibody responses to mycobacterial and self heat shock protein 65 in autoimmune arthritis: epitope specificity and implication in pathogenesis. J Immunol. 2006;177(10):6634–6641
- Strain differences and the role for HSP47 and HSP70 in adjuvant arthritis in rats. Scand J Immunol. 2006;64(6):623–632
- . Heat shock (stress) proteins and autoimmunity in rheumatic diseases. Semin Arthritis Rheum. 1993;22(6):357–374
- . Development of arthritis, periarthritis and periostitis in rats given adjuvants. Proc Soc Exp Biol Med. 1956;91(1):95–101
- . Streptococcal cell-wall-induced arthritis in rats: an overview. Int J Tissue React. 1988;10(1):1–5
- . Suppression of streptococcal cell wall-induced arthritis by human chorionic gonadotropin. Arthritis Rheum. 2000;43(9):2064–2072
- An immunodominant epitope from mycobacterial 65-kDa heat shock protein protects against pristane-induced arthritis. J Immunol. 1998;160(9):4628–4634
- . A 71-kD heat shock protein (hsp) from Mycobacterium tuberculosis has modulatory effects on experimental rat arthritis. Clin Exp Immunol. 1996;103(1):77–82
- . Peptide-induced nasal tolerance for a mycobacterial heat shock protein 60 T cell epitope in rats suppresses both adjuvant arthritis and nonmicrobially induced experimental arthritis. Proc Natl Acad Sci USA. 1997;94(7):3284–3289
- . A conserved mycobacterial heat shock protein (hsp) 70 sequence prevents adjuvant arthritis upon nasal administration and induces IL-10-producing T cells that cross-react with the mammalian self-hsp70 homologue. J Immunol. 2000;164(5):2711–2717
- . Inhibition of adjuvant-induced arthritis by DNA vaccination with the 70-kd or the 90-kd human heat-shock protein: immune cross-regulation with the 60-kd heat-shock protein. Arthritis Rheum. 2004;50(11):3712–3720
- . Tolerization with Hsp65 induces protection against adjuvant-induced arthritis by modulating the antigen-directed interferon-gamma, interleukin-17, and antibody responses. Arthritis Rheum. 2009;60(1):103–113
- A synthetic 10-kD heat shock protein (hsp10) from Mycobacterium tuberculosis modulates adjuvant arthritis. Clin Exp Immunol. 1996;103(3):384–390
- Preventive administration of Mycobacterium tuberculosis 10-kDa heat shock protein (hsp10) suppresses adjuvant arthritis in Lewis rats. Int Immunopharmacol. 2002;2(4):463–474
- Treatment of murine collagen-induced arthritis by the stress protein BiP via interleukin-4-producing regulatory T cells: a novel function for an ancient protein. Arthritis Rheum. 2006;54(3):854–863
- . Gastric administration of recombinant 65 kDa heat shock protein delays the severity of type II collagen induced arthritis in mice. J Rheumatol. 1998;25(4):763–767
- . Protective effects of overexpression TCR Vbeta5.2-HSP70 and TCR Vbeta8.2-HSP70 against collagen-induced arthritis in rats. Cell Mol Immunol. 2007;4(6):439–445
- . Differential mycobacterial 65-kDa heat shock protein T cell epitope recognition after adjuvant arthritis-inducing or protective immunization protocols. J Immunol. 1994;152(7):3656–3664
- . Activation of T cells recognizing self 60-kD heat shock protein can protect against experimental arthritis. J Exp Med. 1995;181(3):943–952
- . The regulatory C-terminal determinants within mycobacterial heat shock protein 65 are cryptic and cross-reactive with the dominant self homologs: implications for the pathogenesis of autoimmune arthritis. J Immunol. 2004;173(1):181–188
- Antirheumatic E. coli extract OM-89 induces T cell responses to HSP60 and 70. Int J Immunopharmacol. 1997;19(9-10):565–568
- . The T cells specific for the carboxyl-terminal determinants of self (rat) heat-shock protein 65 escape tolerance induction and are involved in regulation of autoimmune arthritis. J Immunol. 2004;172(5):2795–2802
- . A mycobacterial 65-kD heat shock protein induces antigen-specific suppression of adjuvant arthritis, but is not itself arthritogenic. J Exp Med. 1990;171(1):339–344
- . Reverse effect of gram-positive bacteria vs. gram-negative bacteria on adjuvant-induced arthritis in germfree rats. Microbiol Immunol. 1985;29(6):487–497
- . Suppressive effect of Escherichia coli on adjuvant-induced arthritis in germ-free rats. Arthritis Rheum. 1986;29(4):547–553
- . HSP70-1 promoter region alleles and susceptibility to rheumatoid arthritis. Clin Exp Rheumatol. 1996;14(2):183–185
- HO-1 promoter polymorphism associated with rheumatoid arthritis. Arthritis Rheum. 2007;56(12):3953–3958
- . HLA class III region and susceptibility to rheumatoid arthritis. Clin Exp Rheumatol. 2000;18(4):485–491
- HMOX1 promoter polymorphism modulates the relationship between disease activity and joint damage in rheumatoid arthritis. Arthritis Rheum. 2008;58(11):3388–3393
- . A novel variant of the MHC-linked hsp70, hsp70-hom, is associated with rheumatoid arthritis. Tissue Antigens. 2000;56(1):38–44
- HSPD1 is not a major susceptibility gene for rheumatoid arthritis in the French Caucasian population. J Hum Genet. 2007;52(12):1036–1039
- Heat shock protein 70 gene polymorphisms in rheumatoid arthritis. Tissue Antigens. 1997;50(1):71–73
- . HLA-DR4 and HLA-DR10 motifs that carry susceptibility to rheumatoid arthritis bind 70-kD heat shock proteins. Nat Med. 1996;2(3):306–310
- . The susceptibility sequence to rheumatoid arthritis is a cross-reactive B cell epitope shared by the Escherichia coli heat shock protein dnaJ and the histocompatibility leukocyte antigen DRB10401 molecule. J Clin Invest. 1992;89(1):327–331
- . Interaction between heat-shock protein 73 and HLA-DRB1 alleles associated or not with rheumatoid arthritis. Arthritis Rheum. 2002;46(4):929–933
- . A function for the QKRAA amino acid motif: mediating binding of DnaJ to DnaK (Implications for the association of rheumatoid arthritis with HLA-DR4). J Clin Invest. 1997;99(8):1818–1822
- Positive selection in autoimmunity: abnormal immune responses to a bacterial dnaJ antigenic determinant in patients with early rheumatoid arthritis. Nat Med. 1995;1(5):448–452
- Possible association of non-binding of HSP70 to HLA-DRB1 peptide sequences and protection from rheumatoid arthritis. Immunogenetics. 2002;54(2):67–73
- . Anti-inflammatory actions of the heme oxygenase-1 pathway. Curr Pharm Des. 2003;9(30):2541–2551
- Heat shock protein 96 is elevated in rheumatoid arthritis and activates macrophages primarily via TLR2 signaling. J Immunol. 2009;182(8):4965–4973
- . Geranylgeranylacetone, a non-toxic inducer of heat shock protein, induces cell death in fibroblast-like synoviocytes from patients with rheumatoid arthritis. Mod Rheumatol. 2009;19(4):379–383
- . Stimulatory response towards the 65 kDa heat shock protein and other mycobacterial antigens in patients with rheumatoid arthritis. J Rheumatol. 1991;18(2):171–176
- . Clonal expansion of mycobacterial heat-shock protein-reactive T lymphocytes in the synovial fluid and blood of rheumatoid arthritis patients. Arthritis Rheum. 1997;40(3):510–519
- Epitope specificity and MHC restriction of rheumatoid arthritis synovial T cell clones which recognize a mycobacterial 65 kDa heat shock protein. Int Immunol. 1991;3(10):965–972
- . Proliferative response of synovial fluid mononuclear cells of patients with rheumatoid arthritis to mycobacterial 65 kDa heat shock protein and its association with HLA-DR+.gamma delta+ T cells. J Rheumatol. 1994;21(8):1403–1408
- . A dominant human leucocyte antigen DR4-Dw15 restricted mycobacterial 65 kDa antigen-specific T-cell immunity in Chinese patients with rheumatoid arthritis. Br J Rheumatol. 1995;34(6):498–506
- Relationship between disease severity and responses by blood mononuclear cells from patients with rheumatoid arthritis to human heat-shock protein 60. Immunology. 2000;99(2):208–214
- . Reactivity patterns of synovial T-cell lines derived from a patient with rheumatoid arthritis. I (Reactions with defined antigens and auto-antigens suggest the existence of multireactive T-cell clones). Scand J Immunol. 1997;46(2):187–194
- . Activation of synovial fluid T lymphocytes by 60-kd heat-shock proteins in patients with inflammatory synovitis. Arthritis Rheum. 1992;35(1):43–48
- . Antibody levels to mycobacteria in relation to HLA type: evidence for non-HLA-linked high levels of antibody to the 65 kD heat shock protein of M. bovis in rheumatoid arthritis. Clin Exp Immunol. 1988;74(2):211–215
- . Stimulation of suppressive T cell responses by human but not bacterial 60-kD heat-shock protein in synovial fluid of patients with rheumatoid arthritis. J Clin Invest. 1997;100(2):459–463
- . In vitro responses to a 65-kilodalton mycobacterial protein by synovial T cells from inflammatory arthritis patients. J Immunol. 1989;143(8):2494–2500
- Mycobacteria and human heat shock protein-specific cytotoxic T lymphocytes in rheumatoid synovial inflammation. Arthritis Rheum. 1992;35(3):270–281
- Epitope-specific immunotherapy induces immune deviation of proinflammatory T cells in rheumatoid arthritis. Proc Natl Acad Sci USA. 2004;101(12):4228–4233
- The stress protein BiP is overexpressed and is a major B and T cell target in rheumatoid arthritis. Arthritis Rheum. 2001;44(4):761–771
- The human endoplasmic reticulum molecular chaperone BiP is an autoantigen for rheumatoid arthritis and prevents the induction of experimental arthritis. J Immunol. 2001;166(3):1492–1498
- . T cell response to human HSP60 and yersinia 19 kDa in ankylosing spondylitis and rheumatoid arthritis: no evidence for a causal role of these antigens in the pathogenesis. Ann Rheum Dis. 2002;61(5):473–474
- . Limiting-dilution analysis of T cell reactivity to mycobacterial antigens in peripheral blood and synovium from rheumatoid arthritis patients. Clin Exp Immunol. 1992;88(3):424–429
- . Limiting dilution analysis of proliferative T cell responses to mycobacterial 65-kDa heat-shock protein fails to show significant frequency differences between synovial fluid and peripheral blood of patients with rheumatoid arthritis. Eur J Immunol. 1991;21(12):2937–2941
- In-vitro effects of Mycobacterium bovis BCG-lysate and its derived heat shock proteins on cytokines secretion by blood mononuclear cells of rheumatoid arthritis patients in comparison with healthy controls. Int Immunopharmacol. 2008;8(6):887–892
- Isolation of an IgG monoclonal anti-dnaJ antibody from an immunoglobulin combinatorial library from a patient with rheumatoid arthritis. J Rheumatol. 1999;26(7):1439–1445
- Immunodominant region of Actinobacillus actinomycetemcomitans 40-kilodalton heat shock protein in patients with rheumatoid arthritis. J Dent Res. 2001;80(1):346–350
- . Rheumatoid arthritis-related antigen 47kDa (RA-A47) is a product of colligin-2 and acts as a human HSP47. J Bone Miner Metab. 2000;18(6):328–334
- Specific serum antibodies against membranous proteins of a human immortal chondrocytic cell line (HCS-2/8) in rheumatoid arthritis and their relationship to the natural history of this disease. J Bone Miner Metab. 1996;14(3):146–152
- Elevated IgG antibody levels to the mycobacterial 65-kDa heat shock protein are characteristic of patients with rheumatoid arthritis. Scand J Immunol. 1989;30(5):519–527
- . Antibodies to the 65 kDa mycobacterial stress protein in west Africans with rheumatoid arthritis, tuberculosis and malaria. Br J Rheumatol. 1995;34(4):352–354
- Preferential binding with Escherichia coli hsp60 of antibodies prevalent in sera from patients with rheumatoid arthritis. Clin Immunol Immunopathol. 1997;82(2):141–148
- . Antibodies to 65 kDa and 70 kDa heat shock proteins in rheumatoid arthritis and systemic lupus erythematosus. Immunol Cell Biol. 1992;70(Pt. 5):295–300
- The B cell repertoire of patients with rheumatoid arthritis (II. Increased frequencies of IgG+ and IgA+ B cells specific for mycobacterial heat-shock protein 60 or human type II collagen in synovial fluid and tissue). Arthritis Rheum. 1997;40(8):1409–1419
- . Antibodies against human 60 kDa heat shock protein are not associated with cardiovascular disease in patients with rheumatoid arthritis. Ann Rheum Dis. 2006;65(5):590–594
- Antibodies to 65Kd heat-shock protein were elevated in rheumatoid arthritis. Clin Rheumatol. 1994;13(2):261–264
- Anti-tumor necrosis factor-alpha therapy augments dipeptidyl peptidase IV activity and decreases autoantibodies to GRP78/BIP and phosphoglucose isomerase in patients with rheumatoid arthritis. J Rheumatol. 2005;32(11):2116–2124
- Anti-heat shock protein 70 kDa and 90 kDa antibodies in serum of patients with rheumatoid arthritis. Ann Rheum Dis. 1999;58(5):291–296
- . Specific antibody response to the mycobacterial 65 kDa stress protein in ankylosing spondylitis and rheumatoid arthritis. Br J Rheumatol. 1990;29(6):426–429
- . The B cell repertoire of patients with rheumatoid arthritis (Frequencies and specificities of peripheral blood B cells reacting with human IgG, human collagens, a mycobacterial heat shock protein and other antigens). Clin Exp Immunol. 1993;92(3):404–411
- Heat-shock protein 65 autoantibodies are differently associated with early atherosclerosis in rheumatoid arthritis and in healthy subjects. Ann NY Acad Sci. 2007;1108:408–413
- . Lack of association of increased antibody levels to mycobacterial hsp65 with rheumatoid arthritis: results from a study of disease discordant twin pairs. Ann Rheum Dis. 1993;52(7):542–544
- Identification of small heat shock protein B8 (HSP22) as a novel TLR4 ligand and potential involvement in the pathogenesis of rheumatoid arthritis. J Immunol. 2006;176(11):7021–7027
- Epitope spreading to citrullinated antigens in mouse models of autoimmune arthritis and demyelination. Arthritis Res Ther. 2008;10(5):R119
- Specific autoantibodies precede the symptoms of rheumatoid arthritis: a study of serial measurements in blood donors. Arthritis Rheum. 2004;50(2):380–386
- Anti-CCP antibodies measured at disease onset help identify seronegative rheumatoid arthritis and predict radiological and functional outcome. Rheumatology (Oxford). 2006;45(4):478–480
- Regulatory role of heme oxygenase 1 in inflammation of rheumatoid arthritis. Arthritis Rheum. 2006;54(4):1132–1142
- Therapeutic efficacy and safety of chaperonin 10 in patients with rheumatoid arthritis: a double-blind randomised trial. Lancet. 2006;368(9538):855–863
- Heat shock protein 10 inhibits lipopolysaccharide-induced inflammatory mediator production. J Biol Chem. 2005;280(6):4037–4047
- . Susceptibility to epitope specific immunotherapy of rheumatoid arthritis relies on the expression of co-stimulatory molecules associated with T cells anergy and tolerance (Abstract number 1848), Abstract supplement 2008 Annual Scientific Meeting. Arthritis Rheum. 2008;58(Suppl 9):845
- Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy. J Exp Med. 2004;200(3):277–285
- . Heat shock protein 60 enhances CD4+ CD25+ regulatory T cell function via innate TLR2 signaling. J Clin Invest. 2006;116(7):2022–2032
- Recognition of human 60 kD heat shock protein by mononuclear cells from patients with juvenile chronic arthritis. Lancet. 1991;337(8754):1368–1372
- Juvenile chronic arthritis: T cell reactivity to human HSP60 in patients with a favorable course of arthritis. J Clin Invest. 1995;95(3):934–940
- The spontaneous remission of juvenile idiopathic arthritis is characterized by CD30+ T cells directed to human heat-shock protein 60 capable of producing the regulatory cytokine interleukin-10. Arthritis Rheum. 2003;48(7):2001–2010
- Autoreactivity to human heat-shock protein 60 predicts disease remission in oligoarticular juvenile rheumatoid arthritis. Arthritis Rheum. 1996;39(11):1826–1832
- . The determinants of susceptibility/resistance to adjuvant arthritis in rats. Arthritis Res Ther. 2009;11(4):239
- . Commensal gut bacteria and the etiopathogenesis of rheumatoid arthritis. J Rheumatol. 2008;35(8):1477–1497
- . What is the role of the metabolic activity of the gut microbiota in inflammatory bowel disease? (Probing for answers with stable isotopes). J Pediatr Gastroenterol Nutr. 2008;46(5):486–495
- . Fecal microbiota in early rheumatoid arthritis. J Rheumatol. 2008;35(8):1500–1505
- . Influence of the bacterial flora on collagen-induced arthritis in susceptible and resistant strains of rats. Clin Exp Rheumatol. 1993;11(1):61–64
- . Environmental modulation of autoimmune arthritis involves the spontaneous microbial induction of T cell responses to regulatory determinants within heat shock protein 65. J Immunol. 2001;166(6):4237–4243
- . Influence of major histocompatibility complex on bacterial composition of fecal flora. Infect Immun. 2001;69(4):2372–2377
- . Predominant role of host genetics in controlling the composition of gut microbiota. PLoS One. 2008;3(8):e3064
- . Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism. Proc Natl Acad Sci USA. 2009;106(34):14728–14733
- Modulation of experimental autoimmunity: treatment of adjuvant arthritis by immunization with a recombinant vaccinia virus. Infect Immun. 1991;59(6):2029–2035
- . Effects of heme oxygenase-1 inducers on established rat adjuvant arthritis. Cell Mol Biol (Noisy-le-grand). 2005;51(5):479–485
- . Experimental immunization with anti-rheumatic bacterial extract OM-89 induces T cell responses to heat shock protein (hsp)60 and hsp70; modulation of peripheral immunological tolerance as its possible mode of action in the treatment of rheumatoid arthritis (RA). Clin Exp Immunol. 1997;110(1):72–78
- . Therapeutic effect of recombinant vaccinia virus expressing the 60-kd heat-shock protein on adjuvant arthritis. Arthritis Rheum. 1994;37(10):1462–1467
- . Induction of IL-10 and inhibition of experimental arthritis are specific features of microbial heat shock proteins that are absent for other evolutionarily conserved immunodominant proteins. J Immunol. 2001;167(8):4147–4153
- . Immunosuppressive effects of the heat shock protein 90-binding antibiotic geldanamycin. Biochem Mol Biol Int. 1999;47(4):587–595
- . Differential effects of immunisation with mycobacterial 65 kD heat shock protein on two models of autoimmunity. Autoimmunity. 1992;14(1):73–77
- . CD4+ Th2 cells specific for mycobacterial 65-kilodalton heat shock protein protect against pristine-induced arthritis. J Immunol. 1997;159(8):3692–3697
- . Comparison between the protective effects of mycobacterial 65-kD heat shock protein and ovomucoid in pristane-induced arthritis: relationship with agalactosyl IgG. Clin Exp Immunol. 1993;94(2):247–251
- Immunomodulation and protection induced by DNA-hsp65 vaccination in an animal model of arthritis. Hum Gene Ther. 2005;16(11):1338–1345
- . Cellular and humoral reactivity pattern to the mycobacterial heat shock protein hsp65 in pristane induced arthritis susceptible and hsp65 protected DBA/1 mice. Autoimmunity. 1991;11(2):89–95
- . Polyarthritis in the rat: effects of tolerance and sensitization to the bacterial extract OM-89 with a possible mode of action. Br J Rheumatol. 1995;34(12):1135–1138
- IL-10 is critically involved in mycobacterial HSP70 induced suppression of proteoglycan-induced arthritis. PLoS ONE. 2009;4(1):e4186
- . A synthetic mycobacterial heat shock peptide prevents adjuvant arthritis but not proteoglycan-induced synovitis in the rat. Agents Actions. 1991;34(1-2):148–150
- . Relationship between collagen-induced and adjuvant arthritis in the Lewis rat. J Autoimmun. 1993;6(6):691–700
- . Overexpression of human homologs of the bacterial DnaJ chaperone in the synovial tissue of patients with rheumatoid arthritis. Arthritis Rheum. 1999;42(2):210–220
- The synovial proteome: analysis of fibroblast-like synoviocytes. Arthritis Res Ther. 2004;6(2):R161–R168
- . Analysis of human 65 kD heat shock protein mRNA using polymerase chain reaction in synovia of rheumatoid arthritis patients. Fukushima J Med Sci. 1995;41(2):95–102
- The development of monoclonal antibodies to the human mitochondrial 60-kd heat-shock protein, and their use in studying the expression of the protein in rheumatoid arthritis. Arthritis Rheum. 1992;35(12):1427–1433
- . Presence of human 65 kD heat shock protein (hsp) in inflamed joints and subcutaneous nodules of RA patients. Scand J Immunol. 1990;31(6):283–288
- Antibodies to the mycobacterial 65-kd heat-shock protein are reactive with synovial tissue of adjuvant arthritic rats and patients with rheumatoid arthritis and osteoarthritis. Am J Pathol. 1990;137(5):1013–1017
- . Aberrant extracellular and dendritic cell (DC) surface expression of heat shock protein (hsp)70 in the rheumatoid joint: possible mechanisms of hsp/DC-mediated cross-priming. J Immunol. 2003;171(11):5736–5742
- Heat shock protein 70 membrane expression on fibroblast-like synovial cells derived from synovial tissue of patients with rheumatoid and juvenile idiopathic arthritis. Scand J Rheumatol. 2006;35(6):447–453
- Enhanced expression of heat shock protein 70 (hsp70) and heat shock factor 1 (HSF1) activation in rheumatoid arthritis synovial tissue (Differential regulation of hsp70 expression and hsf1 activation in synovial fibroblasts by proinflammatory cytokines, shear stress, and antiinflammatory drugs). J Clin Invest. 1998;102(2):302–311
- . The differential expressions of 78-kDa glucose regulated protein of infiltrating plasma cells in peripheral joints with the histopathological variants of rheumatoid synovitis. Arthritis Res Ther. 2009;11(1):R4
- . Continuous enhanced expression of Hsc70 but not Hsp70 in rheumatoid arthritis synovial tissue. Arthritis Rheum. 2004;50(1):88–93
- . Expression of heat shock protein on lymphocytes in peripheral blood and synovial fluid from patients with rheumatoid arthritis. J Rheumatol. 1996;23(12):2027–2032
- . Effect of sulphasalazine on gastrointestinal microflora and on mucosal heat shock protein expression in patients with rheumatoid arthritis. Br J Rheumatol. 1994;33(11):1039–1048
This work was supported by grants from the National Institutes of Health (Bethesda, MD) and the Arthritis Foundation (Atlanta, GA).
The authors have no conflict of interest to disclose.
PII: S0049-0172(09)00122-X
doi: 10.1016/j.semarthrit.2009.10.002
© 2010 Elsevier Inc. All rights reserved.
« Previous
Next »
Seminars in Arthritis and Rheumatism
Volume 40, Issue 2
, Pages 164-175
, October 2010
