Seminars in Arthritis and Rheumatism
Volume 40, Issue 3 , Pages 201-209 , December 2010

Proliferative Glomerulonephritis in Lupus Patients With Human Immunodeficiency Virus Infection: A Difficult Clinical Challenge

  • Simona Gindea, MD

      Affiliations

    • Fellow, Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY
  • ,
  • Julie Schwartzman, MD

      Affiliations

    • Assistant Professor of Medicine, Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY
  • ,
  • Leal C. Herlitz, MD

      Affiliations

    • Assistant Professor of Clinical Pathology and Cell Biology, Columbia University College of Physicians and Surgeons, New York, NY
  • ,
  • Michael Rosenberg, MD, PhD

      Affiliations

    • Associate Professor of Clinical Pediatrics, Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, NY
  • ,
  • Jacobo Abadi, MD

      Affiliations

    • Associate Professor of Clinical Pediatrics, Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, NY
  • ,
  • Chaim Putterman, MD

      Affiliations

    • Chief, Division of Rheumatology and Professor of Medicine and Microbiology & Immunology, Albert Einstein College of Medicine, Bronx, NY
    • Corresponding Author InformationAddress reprint requests to Chaim Putterman, MD, Division of Rheumatology, Albert Einstein College of Medicine, Forchheimer Building, Room 701N, 1300 Morris Park Ave, Bronx, NY 10461

References 

  1. Winchester R, Bernstein DH, Fischer HD, Enlow R, Solomon G. The co-occurrence of Reiter's syndrome and acquired immunodeficiency. Ann Int Med. 1987;106:19–26
  2. Patel N, Patel N, Espinoza LR. HIV infection and rheumatic diseases: the changing spectrum of clinical enigma. Rheum Dis Clin North Am. 2009;35:139–161
  3. Calabrese LH, Kirchner E, Shrestha R. Rheumatic complications of human immunodeficiency virus infection in the era of highly active anti-retroviral therapy: emergence of a new syndrome of immune reconstitution and changing patterns of disease. Semin Arthritis Rheum. 2005;35:166–174
  4. Barthel HR, Wallace DJ. False-positive human immunodeficiency virus testing in patients with lupus erythematosus. Semin Arthritis Rheum. 1993;23:1–7
  5. Kopelman RG, Zolla-Pazner S. Association of human immunodeficiency virus infection and autoimmune phenomena. Am J Med. 1988;84:82–88
  6. Strauss J, Anitbol C, Zilleruelo G, Scott G, Paredes A, Malaga S, et al. Renal disease in children with acquired immunodeficiency syndrome. N Engl J Med. 1989;321:625–630
  7. D'Agati V, Siegle R. Coexistence of AIDS and lupus nephritis: A case report. Am J Nephrol. 1990;10:243–247
  8. Yeh C, Fox PC, Goto Y, Austin HA, Brahim JS, Fox CH. Human immunodeficiency virus (HIV) and HIV infected cells in saliva and salivary glands of a patient with systemic lupus erythematosus. J Rheumatol. 1992;19:1810–1812
  9. Bambery P, Deodhar SD, Malhotra HS, Sehgal S. Blood transfusion related HBV and HIV infection in a patient with SLE. Lupus. 1993;2:203–205
  10. Itoh K, Nishioka Y, Hirohata S, Inoue T, Ito K, Kimura M, et al. HIV induced systemic lupus erythematosus. Lupus. 1994;3:205–206
  11. Lu I, Cohen PR, Grossman ME. Multiple dermatofibromas in a woman with HIV infection and systemic lupus erythematosus. J Am Acad Dermatol. 1995;32:901–903
  12. Byrd VM, Sergent JS. Suppression of systemic lupus erythematosus by the human immunodeficiency virus. J Rheumatol. 1996;23:1295–1296
  13. Furie RA. Effects of human immunodeficiency virus infection on the expression of rheumatic illness. Rheum Dis Clin North Am. 1991;17:177–188
  14. Jindal R, Solomon M, Burruws L. False positive tests for HIV in a woman with lupus and renal failure. N Engl J Med. 1993;328:1281–1282
  15. Molina JF, Citera G, Rosler D, Cuellar ML, Molin J, Felipe O, et al. Coexistence of human immunodeficiency virus infection and systemic lupus erythematosus. J Rheumatol. 1995;22:347–350
  16. Kudava YC, Peterson LS, Holley KE, Wright AJ, Hunder GG. SLE nephropathy in a patient with HIV infection: case report and review of the literature. J Rheumatol. 1996;23:1811–1815
  17. Contreras G, Green DF, Pardo V, Schultz DR, Bourgoignie JJ. Systemic lupus erythematosus in two adults with human immunodeficiency virus infection. Am J Kidney Dis. 1996;28:292–295
  18. Fernandez-Miranda C, Rubio R, Pulido F. Development of acquired immune deficiency syndrome in a patient with systemic lupus erythematosus. J Rheumatol. 1996;23:1308
  19. Fox RA, Isenberg DA. Human immunodeficiency virus infection in systemic lupus erythematosus. Arthritis Rheum. 1997;40:1168–1172
  20. Chang BG, Markowitz GS, Seshan SV, Seigle RL, D'Agatti VD. Renal manifestations of concurrent systemic lupus erythematosus and HIV infections. Am J Kidney Dis. 1999;33:441–449
  21. Maradona JA, Carton JA, Asensi V. Myastenia gravis and systemic lupus erythematosus in association with human immunodeficiency virus infection. Clin Infect Dis. 1995;20:1577–1578
  22. Cimmino MA, DeMaria A, Moggiana G, Parisi M, Querci G, Accardo S. HIV infection in a male patient with systemic lupus erythematosus. Clin Exp Rheumatol. 1996;14:317–320
  23. Smith PR, D'cruz D, Raftery MJ, Dodd SM, Helbert M, Skinner CJ. Drug-induced lupus nephritis in HIV infection. Rheumatology. 1999;39:1047–1048
  24. Clutterbuck DJ, Watson J, De Ruitter A, Godfrey T, Bradbeer C. Presence of HIV infection in patients diagnosed with systemic lupus erythematosus. Rheumatology. 2000;39:1047–1048
  25. Diri E, Lipsky PE, Berggren RE. Emergence of systemic lupus erythematosus after initiation of highly active antiretroviral therapy for human immunodeficiency virus infection. J Rheumatol. 2000;27:2711–2714
  26. Mialou V, Bertrand Y, Bouvier R, Nochy D, Fabien N, Nicoud P, et al. Lupus nephritis in a child with AIDS. Am J Kidney Dis. 2001;37:E27
  27. Daikh BE, Holyst MM. Lupus-specific autoantibodies in a concomitant human immunodeficiency virus and systemic lupus erythematosus: case report and literature review. Semin Arthritis Rheum. 2001;30:418–425
  28. O'Keefe K, Edelheit B, Onel K, Tantawi M, Johann-Liang R. Systemic lupus erythematosus in a pediatric patient with congenital acquired immunodeficiency syndrome. Pediatr Infect Dis J. 2001;20:450–452
  29. Drake WP, Byrd VM, Olsen NJ. Reactivation of systemic lupus erythematosus after initiation of highly active antiretroviral therapy for acquired immunodeficiency syndrome. J Clin Rheumatol. 2003;9:176–180
  30. Wanchu A, Sud A, Singh S, Bambery P. Human immunodeficiency virus infection in a patient with systemic lupus erythematosus. J Assoc Physicians India. 2003;51:1102–1104
  31. Calza L, Manfredi R, Colangeli V, D'Antuono A, Passarini B, Chiodo F. Systemic and discoid lupus erythematosus in HIV-infected patients treated with highly active antiretroviral therapy. Int J STD AIDS. 2003;14:356–359
  32. Gould T, Tikly M. Systemic lupus erythematosus in a patient with human immunodeficiency virus infection—challenges in diagnosis and management. Clin Rheumatol. 2004;23:166–169
  33. Palacios R, Santos J, Valdivielso P, Marquez M. Human immunodeficiency virus infection and systemic lupus erythematosus (An unusual case and a review of the literature). Lupus. 2002;11:60–63
  34. Hazarika I, Chakravarty BP, Dutta S, Mahanta N. Emergence of manifestations of HIV infection in a case of systemic lupus eythematosus following treatment with intravenous cyclophosphamide. Clin Rheumatol. 2005;25:98–100
  35. Colon M, Martinez DE. Clinical remission of systemic lupus erythematosus after human immunodeficiency virus infection. P R Health Sci J. 2007;26:79
  36. Chalom EC, Rezaee F, Mendelson J. Pediatric patient with systemic lupus erythematosus and congenital acquired immunodeficiency syndrome: an unusual case and a review of literature. Pediatr Rheumatol Online J. 2008;6:7
  37. Jakez-Ocampo J, Carrillo-Maravilla E, Richaud-Patin Y, Soto-Vega E, Atisha-Fregoso Y, Llorente L. An unusual multiplex systemic lupus erythematosus family with high prevalence of nephropathy, late-onset disease, and one member with disease-onset post HIV-therapy. J Clin Rheumatol. 2008;14:34–37
  38. Hochberg MC. Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1997;40:1725
  39. Weening JJ, D'Agati VD, Schwarts MM, Seshan SV, Alpers CE, Appel GB, et al. The classification of glomerulonephritis in systemic lupus nephritis revisited. J Am Soc Nephrol. 2004;15:241–250
  40. Austin HA, Boumpas DT, Vaughan EM, Balow JE. Predicting renal outcomes in severe lupus nephritis: contributions of clinical and histologic data. Kidney Int. 1994;45:544–550
  41. Diamond B, Katz JB, Aranov C, Lustgarten D, Scarff MD. The role of somatic mutation in the pathogenic anti-DNA response. Annu Rev Immunol. 1992;10:731–757
  42. Mohan C, Adams S, Stanik V, Datta SK. Nucleosome: a major immunogen for pathogenic autoantibody-inducing T cells of lupus. J Exp Med. 1993;177:1367–1381
  43. Aran AA, Putterman C. Treatment of lupus nephritis: facing the era of immunotherapy. Panminerva Med. 2008;50:235–245
  44. Wofsy D, Seaman WE. Reversal of advanced murine lupus in NZB/NZW F1 mice by treatment with monoclonal antibody to L3T4. J Immunol. 1987;138:3247–3253
  45. Wang X, Huang W, Mihara M, Sinha J, Davidson A. Mechanism of action of combined short-term CTLA4Ig and anti-CD40 ligand in murine systemic lupus erythematosus. J Immunol. 2002;168:2046–2053
  46. Maganti RM, Reveille JD, Williams FM. Therapy insight: the changing spectrum of rheumatic disease in HIV population. Nat Clin Pract Rheumatol. 2008;4:428–438
  47. D'Agati V, Appel GB. Renal pathology of human immunodeficiency virus infection. Semin Nephrol. 1998;18:406–421
  48. Haas M, Kaul S, Eustace JA. HIV-associated immune complex glomerulonephritis with “lupus-like” features: a clinicopathologic study of 14 cases. Kidney Int. 2005;67:1381–1390
  49. Tabechian D, Pattanaik D, Suresh U, Cohn SE, Nadasdy T. Lupus-like nephritis in an HIV-positive patient: report of a case and review of the literature. Clin Nephrol. 2003;60:187–194
  50. Wrone EM, Carey H, Reilly RF. Glomerular lesions in HIV-infected patients. Yale J Biol Med. 1997;70:161–173
  51. Sekigawa I, Kaneko H, Hishikawa T, Hashimoto H, Hirose S, Kaneko Y, et al. HIV infection and SLE: Their pathogenic relationship. Clin Exp Rheum. 1998;16:175–180
  52. Gourley MF, Austin HA, Scott D, Yarboro CH, Vaughn EM, Muir J, et al. Methylprednisolone and cyclophosphamide, alone or in combination, in patients with lupus nephritis (A randomized, controlled trial). Ann Int Med. 1996;125:549–557
  53. Boumpas DT, Austin HA, Vaughn EM, Klippel JH, Steinberg AD, Yarboro CH, et al. Controlled trial of pulse methylprednisolone versus two regimens of pulse cyclophophamide in severe lupus nephritis. Lancet. 1992;340:741–745
  54. Alonso CM, Lozada CJ. Effects of IV cyclophosphamide on HIV viral replication in a patient with systemic lupus erythematosus. Clin Exp Rheumatol. 2000;18:510–512
  55. Illei GG, Austin HA, Crane M, Collins L, Gourley MF, Yarboro CH, et al. Combination therapy with pulse Cyclophosphamide plus pulse Methylprednisolone improves long-term renal outcome without adding toxicity in patients with lupus nephritis. Ann Int Med. 2001;135:248–257
  56. Haroon N, Inman RD. Infectious complications of biological therapy. Curr Opin Rheumatol. 2009;21:397–403
  57. Cepeda EJ, Williams FM, Ishimori ML, Weisman MH, Reveille JD. The use of anti-tumour necrosis factor therapy in HIV-positive individuals with rheumatic disease. Ann Rheum Dis. 2008;67:710–712
  58. Boue F, Gabarre J, Gisselbrecht C, Reynes J, Cheret A, Bonnet F, et al. Phase II trial of CHOP plus Rituximab in patients with HIV-associated non-Hodgkin's lymphoma. J Clin Oncol. 2006;24:4123–4128
  59. Marcelin A, Aaron L, Mateus C, Gyan E, Gorin I, Viard JP, et al. Rituximab therapy for HIV-associated Castleman disease. Blood. 2003;102:2786–2788
  60. Ross CL, Hunt BJ, Wyncoll D, Hodgkiss A, Peters B. HIV, thrombocytopaenic purpura and Rituximab in a violent noncompliant patient. Blood Coagul Fibrinolysis. 2009;20:157–160
  61. Ginzler EM, Aranow C. Mycophenolate Mofetil in lupus nephritis. Lupus. 2005;14:59–64
  62. Margolis D, Heredia A, Gaywee J, Oldach D, Drusano G, Redfield R. Abacavir and mycophenolic acid, an inhibitor of inosine-monophosphate dehydrogenase, have profound and synergistic anti-HIV activity. J Acquir Immune Defic Syndr. 1999;21:362–370
  63. Wrisekoop N, Sankatsing SU, Jansen CA, Roos MT, Otto S, Schuttemaker H, et al. No detrimental immunological effects of mycophenolate mofetil and HAART in treatment-naïve acute and chronic HIV-1-infected patients. AIDS Res Hum Retroviruses. 2005;21:991–996
  64. Coull JJ, Turner D, Melby T, Betts MR, Lanier R, Margolis D. A pilot study of the use of mycopenolate mofetil as a component of therapy for multidrug-resistant HIV-1 infection. J Acquir Immune Defic Syndr. 2001;26:423–434
  65. Garcia F, Plana M, Arnendo M, Brunet M, Castro P, Gil C, et al. Effect of mycophenolate mofetil on immune response and plasma and lymphatic tissue viral load during and after interruption of highly active antiretroviral therapy for patients with chronic HIV infection. J Acquir Immune Defic Syndr. 2004;36:823–830
  66. Stock PG, Roland ME, Carlson L, Freise CE, Roberts JP, Hirose R, et al. Kidney and liver transplantation in human immunodeficiency virus-infected patients: a pilot safety and efficacy study. Transplantation. 2003;76:370–375

PII: S0049-0172(09)00147-4

doi: 10.1016/j.semarthrit.2009.12.001

Seminars in Arthritis and Rheumatism
Volume 40, Issue 3 , Pages 201-209 , December 2010