Seminars in Arthritis and Rheumatism
Volume 40, Issue 4 , Pages 365-368 , February 2011

Tocilizumab in Refractory Adult-Onset Still's Disease with Aseptic Meningitis—Efficacy of Interleukin-6 Blockade and Review of the Literature

  • Girish R. Sabnis, MD

      Affiliations

    • Resident, Rheumatology Services, Department of Medicine, Lokmanya Tilak Municipal Medical College and General Hospital, Sion, Mumbai, India
    • Corresponding Author InformationAddress reprint requests to: Girish R. Sabnis, MD, 89/3, Lane 3, Hindu Colony, Dadar (east), Mumbai 400014, India
    • ,
  • Yojana A. Gokhale, MD

      Affiliations

    • Professor and in charge, Rheumatology Services, Department of Medicine, Lokmanya Tilak Municipal Medical College and General Hospital, Sion, Mumbai, India
    • ,
  • Uday P. Kulkarni, MB, BS

      Affiliations

    • Resident, Rheumatology Services, Department of Medicine, Lokmanya Tilak Municipal Medical College and General Hospital, Sion, Mumbai, India

References 

  1. Desai SS, Allen E, Deodhar A. Miller Fisher syndrome in adult onset Still's disease: case report and review of the literature of other neurological manifestations. Rheumatology. 2002;41:216–222
  2. Woo P, Wilkinson N, Prieur AM, Southwood T, Leone V, Livermore P, et al. Open label phase II trial of single, ascending doses of MRA in Caucasian children with severe systemic juvenile idiopathic arthritis: proof of principle of the efficacy of IL-6 receptor blockade in this type of arthritis and demonstration of prolonged clinical improvement. Arthritis Res Ther. 2005;7:R1281–R1288
  3. Bywaters EGL. Still's disease in the adult. Ann Rheum Dis. 1971;30:121–133
  4. Yamaguchi M, Ohta A, Tsunematsu T, Kasukawa R, Mizushima Y, Kashiwagi H, et al. Preliminary criteria for classification of adult Still's disease. J Rheumatol. 1992;19:424–430
  5. Gonzalez-Hernandez T, Martin-Mola E, Fernandez-Zamorano A, Balsa-Criado A, de Miguel-Mendieta E. Serum ferritin can be useful for diagnosis in adult onset Still's disease. J Rheumatol. 1989;16(3):412–413
  6. Pelkonen P, Swanljung K, Siimes MA. Ferritinemia as an indicator of systemic disease activity in children with systemic juvenile rheumatoid arthritis. Acta Paediatr Scand. 1988;75(1):64–68
  7. Hoshino T, Ohta A, Yang D, Kawamoto M, Kikuchi M, Inoue Y, et al. Elevated serum interleukin 6, interferon-gamma, and tumor necrosis factor-alpha levels in patients with adult Still's disease. J Rheumatol. 1998;25:396–398
  8. Ohta A, Yamaguchi M, Kaneoka H, Nagayoshi T, Hiida M. Adult Still's disease: review of 228 cases from the literature. J Rheumatol. 1987;14:1139–1146
  9. Denault A, Dimopoulos M, Fitzcharles MA. Meningoencephalitis and peripheral neuropathy complicating adult Still's disease. J Rheumatol. 1990;17:698–700
  10. Marie I, Levergue H, Perraudin N, Cailleux N, Lecomte F, Courtois H. Aseptic meningitis and cranial nerve palsy revealing adult-onset Still's disease. Clin Infect Dis. 1999;29:220–221
  11. Fitzgerald AA, Leclercq SA, Yan A, Homik JE, Dinarello CA. Rapid responses to anakinra in patients with refractory adult-onset Still's disease. Arthritis Rheum. 2005;52:1794–1803
  12. Iwamoto M, Nara H, Hirata D, Minota S, Nishimoto N, Yoshizaki K. Humanized monoclonal antiinterleukin-6 receptor antibody for treatment of intractable adult-onset Still's disease. Arthritis Rheum. 2002;46:3388–3389
  13. Nakahara H, Mima T, Yoshio-Hoshino N, Matsushita M, Hashimoto J, Nishimoto N. A case report of a patient with refractory adult-onset Still's disease who was successfully treated with tocilizumab over 6 years. Mod Rheumatol. 2009;16:69–72
  14. Bandt DM, Saint-Marcoux B. Tocilizumab for multirefractory adult-onset Still's disease. Ann Rheum Dis. 2009;68:153–154
  15. Matsumoto K, Nagashima T, Takatori S, Kawahara Y, Yagi M, Iwamoto M, et al. Glucocorticoid and cyclosporine refractory adult onset Still's disease successfully treated with Tocilizumab. Clin Rheumatol. 2009;28:485–487
  16. Mima T, Nishimoto N. Clinical value of blocking IL-6 receptor. Curr Opin Rheumatol. 2009;21:224–230

PII: S0049-0172(10)00076-4

doi: 10.1016/j.semarthrit.2010.05.003

Seminars in Arthritis and Rheumatism
Volume 40, Issue 4 , Pages 365-368 , February 2011

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